Sincere advice! Everyone with gout should learn about these two new drugs as soon as possible.

As a rheumatologist, I often encounter patients who are suffering greatly from gout.The sudden joint pain, often occurring in the bi

As a rheumatologist, I often encounter patients who are suffering greatly from gout.The sudden joint pain, often occurring in the big toe, knee joints, etc., is red, swollen, hot, and painful, making it difficult to walk.It feels as if a fierce tiger is biting, hence gout was also called “White Tiger’s Joint” in ancient times.Recently, patients often ask about two new drugs that have just hit the market, namelyDotinurad（Dotinurad）andFirsekibart（Firsekibart）.

If you ask me how these two new drugs are, the simple summary is that they aremore precise, safer, longer-lasting, and suitable for a wider range of people. They can not only quickly relieve pain and prevent recurrence in the long term but also further reduce the risk of liver damage.

As for the specifics, let’s talk about it in detail today.

Gout: More Than Just “Eaten Out” Joint Pain

Many people believe that gout is simply the result of overindulging in seafood and alcohol. This is true to some extent, as a high-purine diet is indeed an important trigger, but the essence of gout is hyperuricemia. Our body metabolizes and produces uric acid, and when the concentration of uric acid in the blood is too high, urate crystals will precipitate like salt, forming small crystals that deposit in joints, skin, and even the kidneys.

These urate crystals in the joints may be harmless under normal circumstances(asymptomatic hyperuricemia phase).Once a “trigger” is encountered, such as injury, cold, or overeating, they are seen as “foreign invaders” by the immune system, immediately causing a severe inflammatory “war” – this is the acute attack of gout.

If gout is not controlled in the long term, the consequences can be severe:

Recurrent attacks:From once or twice a year to several times a month, severely affecting the quality of life.